Scientific Testing and Kolorex Horopito Product News

Kolorex products are backed by scientific research.

Horopito & Polygodial – Proven Anti-Candida Herb

In 1982, researchers at Canterbury University published compelling results showing the extraordinary antifungal activity of Horopito extracts against the yeast-like fungus Candida albicans. This activity is due to the main active ingredient, polygodial.

Since the identification of polygodial in horopito, there have been numerous scientific papers published confirming both in vitro and in vivo this unique and effective antifungal activity.

Download our Scientific Summary to find out more.

The graph below shows that an extract from New Zealand’s Horopito plant containing polygodial was more effective at killing Candida albicans than Amphotericin B, a powerful antifungal pharmaceutical drug used for fungal infections.

This graph shows polygodial has a stronger and faster antifungal action than Amphotericin B.
(Reference: McCallion et al 1982. Planta Medica, vol 44, pp134-138)

Three years later, Forest Herbs Research began developing ways to offer this ancient herb’s Candida killing benefits to you in Kolorex’s Horopito-based range of natural health products.

Traditional Usage – A History of Safe Remedial Use

Plants that contain polygodial have safely and routinely been used as food and medicine in countries like New Zealand, Japan, South America and Africa for centuries. Polygodial and Horopito have also undergone extensive scientific testing to ensure they are safe for external and internal human use. The Maori of New Zealand have long used it as an ingredient in their traditional remedies by chewing the leaves and spitting the juice onto the skin to ease irritation. Early European settlers boiled Horopito leaves and drank the tea to cure an upset stomach.

Ongoing Scientific Testing – Monitoring Efficacy

Horopito leaf, Horopito extract and Kolorex products are scientifically tested by Cawthron Institute and Southern Cross Plant Science to check antifungal efficacy against Candida albicans and to assay the polygodial content.

Each batch of Kolorex softgels undergoes a challenge test for efficacy. In the laboratory the sample is inoculated with approximately one million live colonies of Candida albicans. The number of colonies are monitored and measured after three and seven days to ensure efficacy.

Each supercritical CO2 oleoresin extract of Horopito used in our softgels is analysed to determine the polygodial content. Polygodial is the compound which ensures antifungal activity against Candida albicans and gives Kolorex creams their heat, and soft gels their peppery, pungent taste. The more intense the sensation is on the tongue, the stronger the antifungal power.

Sustainable Farming of Kolorex Horopito

Forest Herbs Research sampled many wild-growing varieties of Horopito. They discovered a five times variation between populations in effectiveness against Candida albicans. Forest Herbs Research then spent years learning how to domesticate and sustainably harvest these slow growing shrubs, eventually planting two farms with the variety that is most powerful against Candida albicans. These are known as Kolorex Horopito.

Horopito leaves are such good defenders against fungi and predators, that the plants have been able to survive largely unchanged for 65 million years. It is one of the world’s oldest flowering plants. It has a very primitive vascular (water transporting) system, however, so it dies quickly if the ground is dry. Forest Herb’s solution is to locate both its farms next to the temperate rainforests of the Kahurangi National Park.